Richard L. Schowen

Academic Degrees

• B.S., 1958, University of California at Berkeley
• Ph.D., 1962, Massachusetts Institute of Technology

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Areas of Specialization

Bio-organic Chemistry

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Research Interests

Organic chemistry: reaction mechanisms, bioorganic chemistry, catalysis, isotope effects

Professor Schowen has closed his research groups, but continues to work in collaboration with colleagues at Kansas and elsewhere. Active programs at Kansas include these projects: (1) Studies of the mechanism, involvement of protein dynamics, and antiparasitic drug design for S-adenosylhomocysteine hydrolases (led by R.T. Borchardt with collaboration by J. Fang, Lynne Howell [Toronto], Carey Johnson, Krzysztof Kuczera, C.R. Middaugh, and Morris Robins [Brigham Young University]); (2) Design and characterization of “green catalysts” with R.S. Givens and others in the NSF Center for Environmentally Beneficial Catalysis, led by Daryle Busch and Bala Subramaniam; (3) Protium-deuterium exchange in the amorphous solid state as a measure of protein mobility, led by Elizabeth M. Topp.

NOTE: Persons who wish research positions should apply to Professor Schowen's younger colleagues.

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Selected publications

Schowen, R.L. Model studies of hydride transfer, In: Hynes, J.T.; Klinman, J.P.; Limbach, H.-H., Schowen, R.L. (Eds.) Hydrogen-Transfer Reactions, VCH-Wiley, Weinheim, 2006: pp 1037-1077.

Schowen, R.L., with Hynes, J.T.; Klinman, J.P.; Limbach, H.-H. (Eds.) Hydrogen-Transfer Reactions, VCH-Wiley, Weinheim, 2006 (1559 pages, 4 volumes): vols. 1 and 2 (Physical and chemical aspects of hydrogen transfer: Hynes, J.T.; Limbach, H.H., Eds.), vols. 3 and 4 (Biological aspects of hydrogen transfer: Klinman, J.P.; Schowen, R.L., Eds.).

Schowen, R.L. Isotopic and other studies on the molecular origins of substrate regulation of pyruvate decarboxylases: a reconsideration, Isotopes in Enviromental and Health Studies 2007, 43, 1 - 16.

Schowen, R.L. Proenzymes. In: Stella, V.J.; Borchardt, R.T.; Hageman, M.J.; Oliyai, R.; Tilley, J.; Maag, H., Eds. Prodrugs: Challenges and Rewards, AAPS Press, New York, 2007, Part 1, pp 417-428.

Gradinaru, Robert; Schowen, Richard; Ghisla, Sandro. Solvent Isotope Effects in Reactions of Human Medium-Chain Acyl-CoA Dehydrogenase Active Site Mutants. Biochemistry  2007,  46(9),  2497-2509.

Qing-Shan Li; Sumin Cai; Ronald T. Borchardt; Jianwen Fang; Krzysztof Kuczera; C. Russell Middaugh; Richard L.  Schowen, Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 1. Basic features of the association and dissociation processes, Biochemistry, 2007, 46, 5798-5809.

Y. Li, T. D. Williams, R. L. Schowen, E. M. Topp, Trehalose and calcium exert site-specific effects on calmodulin conformation in amorphous solids, Biotechnology and Bioengineering, 2007, 97, 1650-1653.

Y. Li, E.M. Topp, R.L. Schowen, Characterizing protein structure in amorphous solids using hydrogen/deuterium exchange with mass spectrometry, Anal Biochem. 2007, 366. 18-28.