Areas of Specialization
Organic Chemistry, Asymmetric Catalysis, Total Synthesis of Natural Products
- B.S. Western Michigan University, 2005
- Ph.D. Northwestern University, 2010
- Postdoctoral Associate, Princeton University, 2010-2013
Research in the Clift group will focus heavily on the development of new methods for asymmetric catalysis. Drawing inspiration from coenzymes used in biological systems, we seek to discover novel synthetic strategies that will enable a diverse range of enantioselective transformations.
Specifically, we are interested in the development of new organocatalytic reaction manifolds that will enable a variety of C−C bond forming events through C−H functionalization. The successful pursuit of these goals is expected to deliver synthetic methods that will facilitate previously challenging or even impossible chemical transformations. In a broader context, this work will ultimately accelerate the construction of biologically relevant natural products and other medicinal agents by providing new means for the strategic disconnection of these valuable synthetic targets.
- Total Synthesis of the Galbulimima Alkaloid (−)-GB17. Larson, R. T.; Clift, M. D.; Thomson, R. J. Angew. Chem. Int. Ed. Engl. 2012, 51, 2481–2484.
- Enantioselective Total Synthesis and Confirmation of the Absolute and Relative Stereochemistry of Streptorubin B, Hu, D. X.; Clift, M. D. and Thomson, R. J. J. Am. Chem. Soc. 2011, 133, 1799–1804.
- Development of a Merged Conjugate Addition/Oxidative Coupling Sequence. Application to the Enantioselective Total Synthesis of Metacycloprodigiosin and Prodigiosin R1, Clift, M. D. and Thomson, R. J. J. Am. Chem. Soc. 2009, 131, 14579–14583.
- Oxidative Carbon–Carbon Bond Formation via Silyl Bis-enol Ethers: Controlled Cross-coupling for the Synthesis of Quaternary Centers, Clift, M. D.; Taylor, C. N.; Thomson, R. J. Org. Lett. 2007, 9, 4667–4669.
- Enantiomers of 4-Amino-3-fluorobutanoic Acid as Substrates for γ-Aminobutyric Acid Aminotransferase. Conformational Probes for GABA Binding, Clift, M. D.; Ji, H.; Deniau, G. P.; O’Hagan, D.; Silverman, R. B. Biochemistry 2007, 46, 13819–13828.