My Ph.D. research in Dublin City University involved the investigation of some chromatographic and electrophoretic separations for both clinical and industrial applications. Chromatographic techniques, such as high performance liquid chromatography (HPLC) and ion chromatography (IC), have traditionally been employed in the analysis of a variety of analytes, such as inorganic anions, organic acids and pharmaceuticals. Capillary electrophoresis (CE) methods have recently been developed for their analysis and it is an ideal method due to its low sample and material consumption and increased separation efficiencies. The primary analytical techniques used were HPLC with mass spectrometric detection and CE coupled to both electrochemical and fluorescence detection. Currently, my research involves the development of a capillary HPLC method, with electrochemical detection, for the separation of some neurotransmitters. The development of the analytical method is compatible with the small volume and high ionic strength samples generated by microdialysis sampling.