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1251 Wescoe Hall Drive Malott Hall, Room 4027 University of Kansas Lawrence, KS 66045 Phone: (785) 864-3094 Fax: (785) 864-5396 Email: phanson@ku.edu |
Synthetic methods, natural product synthesis, transition metal-catalyzed methods, asymmetric methods,
S- and P-heterocycles, immobilized reagent development, drug discovery and delivery, and
chemical methods for library development.
The major goal of our research program is the development of new synthetic methods for use in drug discovery and natural product synthesis. In particular, we have focused our attention on the utilization of transition metal-catalyzed methods as a means to produce new heterocycles containing sulfur and phosphorus (S- and P-heterocycles) that exhibit both biological and synthetic utility. Central to this goal is the development of phosphorus tethered processes in the synthesis of complex, biologically relevant natural products.
Another facet of our program is aimed at the development of immobilized reagents for use in drug discovery. We are currently employing ring-opening metathesis (ROM) polymerization to generate high-load oligomers with tuneable properties as tools for organic synthesis and library production. We have a long-standing interest in the establishing new chemical methods for library development.
Whitehead, A.; McParland, J.; Hanson, P. R. Divalent Activation in Temporary Phosphate Tethers: Highly Selective Cuprate Displacement Reactions Org. Lett. 2006, 8, 5025-5028.
Herpel, R. H.; Vedantham, P.; Flynn, D. L.; Hanson, P. R. High-Load, Oligomeric Phosphonyl Dichloride: Facile Generation via ROM Polymerization and Application to Scavenging Amines. Tetrahedron Lett. 2006, 47, 6429-6432.
Waetzig, J. D.; Hanson, P. R. Temporary Phosphate Tethers: A Metathesis Strategy to Differentiated Polyol Subunits. Org. Lett. 2006, 8, 1673-1676.
Harned, A. M.; Sherrill, W. M.; Flynn, D. L.; Hanson, P. R. High-Load, Soluble Oligomeric Benzenesulfonyl Azide: Application to Facile Diazo-Transfer Reactions.Tetrahedron 2005, 61, 12093-12099.
Stoianova, D. S.; Whitehead, A.; Hanson, P. R. Stereoselective Routes to Phosphono Sugars. J. Org. Chem. 2005,70, 5880-5889.
Whitehead, A.; McReynolds, M.D.; Moore, J.D.; Hanson, P. R.; Multivalent Activation in Phosphate Tethers: A New Tether for Small Molecule Synthesis. Org. Lett. 2005, 7,3375-3378.
Dougherty, J. M.; Jiménez, M.; Hanson, P. R. Synthesis of Cyclic Sulfamoyl Carbamates and Ureas via Ring-Closing Metathesis. Tetrahedron 2005, 61, 6218-6230 .
Harned, A. M.; Zhang, M.; Vedantham, P.; Mukherjee, S.; Herpel, R. H.; Flynn, D. L.; Hanson, P. R. ROM Polymerization in Facilitated Synthesis. Aldrichimica Acta 2005, 38, 3-16.
Harned,A. M.; Song He, H.; Toy P. H.; Flynn, D. L.; Hanson, P. R. Multipolymer Solution-Phase Reactions: Application to the Mitsunobu Reaction. J. Am. Chem. Soc. 2005,127, 52-53.
Zhang, M., Vedantham, P.; Flynn, D. L., Hanson, P. R. High-Load, Soluble Oligomeric Carbodiimide: Synthesis and Application in Coupling Reactions. J. Org. Chem. 2004, 69, 8340-8344.
McReynolds, M. D.; Dougherty, J. M.; Hanson, P. R. Synthesis of Phosphorus and Sulfur Heterocycles via Ring-Closing Olefin Metathesis. Chem. Rev. 2004, 104, 2239-2258.
Harned, A. M.; Probst, D. A.; Hanson, P. R. The Use of Olefin Metathesis in Combinatorial Chemistry: Supported and Chromatography-Free Syntheses. in Handbook of Metathesis. Grubbs, R. H., Ed.: Wiley-VCH: Weinheim, 2003. pp 361-402.
Moore, J. D.; Hanson, P. R. Substituent Effects in the Double Diastereotopic Differentiation of a -Diazophosphonates via Intramolecular Cyclopropanation. Tetrahedron: Asymmetry 2003, 14, 873-880.
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